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Anti-inflammatory action of steroid inhalers.
Artículo en Inglés | IMSEAR | ID: sea-85006
ABSTRACT
With mucosal inflammation contributing to the pathogenesis of asthma, it is increasingly accepted that long term steroid inhalers may induce remission in chronic long standing asthmatics. The present study involved 44 stable asthmatics who were randomly given either beclomethasone dipropionate inhaler (50 ug) 2 puffs qds or salbutamol inhaler (100 mcg) 2 puffs tds in addition to their oral bronchodilators. Pulmonary function testing, bronchoalveolar lavage and complete blood count were done at basal and weekly intervals and at the end of the study. The absolute eosinophil count showed a significant drop in the beclomethasone group as compared to the salbutamol group. Serial lung functions showed a significant improvement in the pre-bronchodilator PEFR and the pre-bronchodilator FVC in the beclomethasone group as compared to the salbutamol group. There was no significant change in the lavage eosinophil count pre and post-bronchodilator in both groups. Steroid inhalers are thus useful in long term management of bronchial asthma especially with respect to reducing bronchodilator requirement.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Asma / Administración por Inhalación / Femenino / Humanos / Masculino / Beclometasona / Enfermedad Crónica / Adulto / Albuterol / Persona de Mediana Edad Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Año: 1993 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Asma / Administración por Inhalación / Femenino / Humanos / Masculino / Beclometasona / Enfermedad Crónica / Adulto / Albuterol / Persona de Mediana Edad Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Año: 1993 Tipo del documento: Artículo