Oxidant stress in pre-eclampsia and essential hypertension.
Artículo
en Inglés
| IMSEAR
| ID: sea-86296
ABSTRACT
BACKGROUND:
Endothelial cell dysfunction may play a role in the pathobiology of pre-eclampsia and human essential hypertension. Vasodilators and platelet anti-aggregators such as prostacyclin and nitric oxide are produced by endothelial cells. The half-life of prostacyclin and nitric oxide are reduced by superoxide anion, whereas superoxide dismutase antagonizes its action.OBJECTIVES:
To estimate the plasma concentrations of nitric oxide and lipid peroxides and those of catalase and superoxide dismutase in patients with pre-eclampsia and essential hypertension.METHODS:
Patients of essential hypertension and pre-eclampsia were selected for the study. Nitric oxide and lipid peroxides were estimated in the plasma and anti-oxidants catalase and superoxide dismutase were estimated in the RBC membranes.RESULTS:
The ratio between lipid peroxides and nitric oxide was elevated and the activity of superoxide dismutase reduced in patients with pre-eclampsia and uncontrolled essential hypertension.CONCLUSION:
These results suggest that oxidants and anti-oxidants are altered in human essential hypertension and pre-eclampsia.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Preeclampsia
/
Superóxido Dismutasa
/
Vitamina E
/
Femenino
/
Humanos
/
Masculino
/
Embarazo
/
Catalasa
/
Estrés Oxidativo
/
Adulto
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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