Effect of captopril on serum angiotensin converting enzyme and blood pressure in hypertensive patients.
Artículo
en Inglés
| IMSEAR
| ID: sea-86361
ABSTRACT
The effect of chronic captopril therapy on serum angiotensin converting enzyme (ACE) was studied in 30 patients with essential hypertension. Patients were assessed for serum ACE levels serially every week for 4 weeks. Thirty healthy individuals served as controls. The basal serum ACE level among hypertensives (57.4 +/- 37.2 u/l) was found to be significantly higher (p < 0.001) than the controls (33.3 +/- 8.8 u/l). One week after starting captopril therapy, serum ACE levels fell to almost half the basal values (p < 0.001). However, thereafter, it rose to levels higher than the basal level even though the blood pressure remained well controlled. Our study suggests that besides its action on ACE, captopril may lower the blood pressure by other mechanisms as well.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Valores de Referencia
/
Determinación de la Presión Sanguínea
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Inhibidores de la Enzima Convertidora de Angiotensina
/
Captopril
/
Estudios de Seguimiento
/
Resultado del Tratamiento
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Año:
1996
Tipo del documento:
Artículo
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