Hematopoietic growth factors in drug-induced agranulocytosis.
Artículo
en Inglés
| IMSEAR
| ID: sea-90702
ABSTRACT
Drug-induced agranulocytosis (DIA) is a potentially fatal disorder. Hematopoietic growth factors have been used in the treatment of DIA. We report nine cases of DIA treated with granulocyte macrophage - colony stimulating factor (GM-CSF) in a dose of 300 microg/day. All the patients had evidence of systemic infection. Mean time to reach an absolute neutrophil count of 0.5 x 10(9)/L was three days. One patient succumbed to the disease. The cause of death was multiorgan failure. No adverse events were observed with GM-CSF. We conclude that hematopoietic growth factors are useful in shortening the period of neutropenia and reducing morbidity and mortality in these patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Sulfasalazina
/
Femenino
/
Humanos
/
Masculino
/
Clorpromazina
/
Dipirona
/
Estudios Retrospectivos
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Adolescente
/
Resultado del Tratamiento
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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