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Primary HIV-1 infection--a "window of opportunity" for healthcare providers.
Artículo en Inglés | IMSEAR | ID: sea-91254
ABSTRACT
The diagnosis of primary HIV-1 infection (PHI) is often missed and requires a high index of suspicion and a thorough knowledge of laboratory methods. We report the case of a young promiscuous male who presented with fever, rash and neurological symptoms 8 weeks after unprotected sexual exposure. Clinical and laboratory investigations showed the presence of leucopenia and thrombocytopenia with elevated transaminases, and a normal cerebrospinal fluid analysis, while CNS imaging revealed a vasculitis-like involvement of the corpus callosum. Symptoms resolved spontaneously over 3 weeks. Fourth generation ELISA with p24 antigen assay was positive with high HIV-1 RNA load while Western-Blot was negative, thus confirming the diagnosis of PHI. The patient was subsequently started on antiretroviral therapy (ART) and showed undetectable viral load after 8 weeks of therapy. We present the differential diagnoses which need to be entertained as well as the pros and cons of very early ART intervention.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Masculino / ARN / Ensayo de Inmunoadsorción Enzimática / Infecciones por VIH / VIH-1 / Antirreumáticos / Fármacos Anti-VIH / Adulto / Diagnóstico Diferencial Tipo de estudio: Estudio diagnóstico Idioma: Inglés Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Masculino / ARN / Ensayo de Inmunoadsorción Enzimática / Infecciones por VIH / VIH-1 / Antirreumáticos / Fármacos Anti-VIH / Adulto / Diagnóstico Diferencial Tipo de estudio: Estudio diagnóstico Idioma: Inglés Año: 2008 Tipo del documento: Artículo