Spontaneously developing autoantibody to factor VIII in an elderly woman: diagnostic and therapeutic challenges.
Artículo
en Inglés
| IMSEAR
| ID: sea-93065
ABSTRACT
An elderly woman with a continuously bleeding small wound was investigated for the presence of antibodies to FVIII using activated partial time-based screening and confirmatory tests. A late acting coagulation factor inhibitor was detected. The same was characterised to be a low titre antibody against FVIII (5.2 Bethesda units). Cryoprecipitate infusions, corticosteroids and topical desmopressin were unsuccessful in controlling the bleeding. Addition of cyclophosphamide brought about stoppage of bleeding and disappearance of the autoantibody.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tiempo de Tromboplastina Parcial
/
Autoanticuerpos
/
Anciano
/
Femenino
/
Humanos
/
Factor VIII
/
Fibrinógeno
/
Hemorragia
Tipo de estudio:
Estudio diagnóstico
Idioma:
Inglés
Año:
2004
Tipo del documento:
Artículo
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