"An analysis of epileptic patients nonresponsive to drugs".
Artículo
en Inglés
| IMSEAR
| ID: sea-93307
ABSTRACT
Fifty-four consecutively referred patients with uncontrolled epilepsy were subjected to Therapeutic Drug Monitoring on an out patient basis. Regular 2 weekly follow up for a minimum period of 2 months was done, after altering the drug dosage and bringing plasma level(s) within therapeutic range. Plasma levels of Phenobarbitone, Phenytoin and Carbamezepine were done by High Pressure Liquid Chromatography. Eventually, 24 patients were controlled and 30 remained uncontrolled. Significant differences between these 2 groups were found, as regards, duration of epilepsy (p < 0.01), associated mental retardation (p < 0.02), initial carbamazepine dosage and plasma levels in patients on carbamazepine montherapy (p < 0.02 and P < 0.01, respectively) and final phenytoin plasma levels in patients on combined therapy with phenobarbitone and phenytoin (p < 0.05). This study emphasizes the importance of early diagnosis and treatment of epilepsy with the help of plasma level monitoring of anti-epileptic drugs.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenobarbital
/
Fenitoína
/
Femenino
/
Humanos
/
Masculino
/
Esquema de Medicación
/
Carbamazepina
/
Monitoreo de Drogas
/
Insuficiencia del Tratamiento
/
Quimioterapia Combinada
Tipo de estudio:
Estudio de tamizaje
Idioma:
Inglés
Año:
1992
Tipo del documento:
Artículo
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