Neuroprotective agents in acute ischemic stroke.
Artículo
en Inglés
| IMSEAR
| ID: sea-94502
ABSTRACT
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ácidos Pipecólicos
/
Piperidinas
/
Quinoxalinas
/
Ratas
/
Tiazoles
/
Anciano
/
Humanos
/
Bloqueadores de los Canales de Calcio
/
Daño por Reperfusión
/
Clormetiazol
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS