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Cardiac involvement in Wilson's disease--an electrocardiographic observation.
Artículo en Inglés | IMSEAR | ID: sea-94531
ABSTRACT

BACKGROUND:

Wilson's disease is known for its protean manifestations; however electrocardiographic abnormalities have not received much attention.

AIM:

To evaluate the various electrocardiographic (ECG) changes in patients with Wilson's disease.

METHOD:

The resting ECGs of 50 patients with Wilson's disease were systematically analyzed independently by three observers after excluding other causes that could induce ECG abnormalities.

RESULT:

Fifteen patients had at least one abnormality in the ECG. Sinus tachycardia was seen in eight and sinus bradycardia in six. Other abnormalities included bifid P wave (1), ST elevation (2), ST depression (2), T inversion (4), ventricular premature contraction - VPC (1) and prominent U waves (1). QRS axis, PR interval, QRS complex, R/S amplitude ratio and QT interval were normal in all. Ventricular premature beats were not recorded in any. None had features of ventricular hypertrophy. There was no statistically significant difference in ECG abnormalities with reference to age, gender, duration of illness or treatment, serum copper or ceruloplasmin, and severity of neurological impairment.

CONCLUSION:

ECG abnormalities are not uncommon in Wilson's disease and are presumably related to an underlying cardiomyopathy due to deposition of copper in heart.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Taquicardia Sinusal / Bradicardia / Femenino / Humanos / Masculino / Niño / Estudios de Cohortes / Adolescente / Adulto / Electrocardiografía Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Idioma: Inglés Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Taquicardia Sinusal / Bradicardia / Femenino / Humanos / Masculino / Niño / Estudios de Cohortes / Adolescente / Adulto / Electrocardiografía Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Idioma: Inglés Año: 2004 Tipo del documento: Artículo