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Comparative efficacy and tolerability of nimesulide and piroxicam in osteoarthritis with specific reference to chondroprotection: a double blind randomised study.
J Indian Med Assoc ; 1999 Oct; 97(10): 442-5
Artículo en Inglés | IMSEAR | ID: sea-97562
ABSTRACT
The aim of the study was to assess the efficacy, tolerability and chondroprotection afforded by nimesulide, a selective cyclooxygenase-2 inhibitor and piroxicam in a randomised, double blind, controlled clinical trial in 90 patients suffering from osteoarthritis of the knee joint. A significant improvement in the osteoarthritis severity index at 2 weeks (p < 0.01) and an improvement in physicians assessment of global arthritic condition at 4 weeks (p < 0.01) was seen with both the treatments. A significant decrease in articular index of joint tenderness (p < 0.05) at 8 weeks and in self assessment of handicap at 4 weeks (p < 0.05), in comparison to baseline, was observed only in patients receiving nimesulide. Rescue therapy was required by a greater percentage of patients being administered piroxicam. Functional capacity improved in 64% of the patients on nimesulide and 74.5% of the patients receiving piroxicam. Adverse effects were observed in 6 patients on nimesulide and 9 patients receiving piroxicam. No significant difference was found in any of the efficacy and tolerability parameters between the two treatment groups. Magnetic resonance imaging evaluation of the knee joint of 10 patients showed no significant change in the articular cartilage and associated joint structures after 6 months of therapy with both the treatments. The results show that nimesulide and piroxicam are comparable in efficacy and tolerability in patients suffering from osteoarthritis.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Sulfonamidas / Índice de Severidad de la Enfermedad / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Imagen por Resonancia Magnética / Cartílago Articular / Piroxicam Tipo de estudio: Ensayo Clínico Controlado Límite: Aged80 Idioma: Inglés Revista: J Indian Med Assoc Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Sulfonamidas / Índice de Severidad de la Enfermedad / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Imagen por Resonancia Magnética / Cartílago Articular / Piroxicam Tipo de estudio: Ensayo Clínico Controlado Límite: Aged80 Idioma: Inglés Revista: J Indian Med Assoc Año: 1999 Tipo del documento: Artículo