Impact of Familial Pseudohyperkalemia on Donated Blood and Clinical Outcomes from Transfusion / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 87-91, 2023.
Article
en En
| WPRIM
| ID: wpr-1002097
Biblioteca responsable:
WPRO
ABSTRACT
Familial pseudohyperkalemia (FP) is a dominantly inherited condition caused by variants in the gene ABCB6 resulting in red blood cell (RBC) membrane protein defects. FP is generally asymptomatic. However, FP RBCs have an increased permeability to monovalent cations when stored below 37°C. Transfusion of RBC components donated by FP individuals can induce hyperkalemia and may be causally related to transfusion-associated hyperkalemic cardiac arrest, particularly in neonates and infants. Therefore it is necessary to accurately evaluate the frequency of FP occurrence in the Korean population and assess whether FP RBCs have significantly higher supernatant potassium levels. Efforts should be made to recognize the effects of blood products collected from FP donors on blood transfusion recipients to reduce the risk of hyperkalemia, especially in fetuses, infants, and patients at risk of this condition.
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Índice:
WPRIM
Idioma:
En
Revista:
Korean Journal of Blood Transfusion
Año:
2023
Tipo del documento:
Article