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Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 1171-1178, 2004.
Artículo en Coreano | WPRIM | ID: wpr-100308
ABSTRACT

OBJECTIVE:

To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle.

METHODS:

Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test.

RESULTS:

The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis.

CONCLUSION:

We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ARN / ARN Mensajero / Reacción en Cadena de la Polimerasa / ADN Complementario / Angiopoyetina 1 / Angiopoyetina 2 / Endometriosis / Endometrio / Fase Folicular / Ciclo Menstrual Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ARN / ARN Mensajero / Reacción en Cadena de la Polimerasa / ADN Complementario / Angiopoyetina 1 / Angiopoyetina 2 / Endometriosis / Endometrio / Fase Folicular / Ciclo Menstrual Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2004 Tipo del documento: Artículo