Your browser doesn't support javascript.
loading
Cloning and Expression Pattern of FSTL1 mRNA in Normal Myometrium and Uterine Leiomyoma / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 1086-1092, 2004.
Artículo en Coreano | WPRIM | ID: wpr-100320
ABSTRACT

OBJECTIVE:

To study the influence and cloning of differentially expressed genes in human female normal myometrium and uterine leiomyoma tissue.

METHODS:

In this experiment, human uterus tissues (n=25) were taken for total RNA isolation by using Trizol reagent. Differential display was performed by using GeneFishingTM DEG Kit and processed to cDNA sequencing and gene cloning for Follistatin-like 1 (FSTL1). Data were analyzed with the image Master VDS software and statistical significance was defined as p<0.05 by paired t test results.

RESULTS:

FSTL1 mRNA expression level was significantly higher (p<0.05) in normal and adjacent normal myometrium tissues than uterine leiomyoma tissue of women in the reproductive age. Whereas in the menopausal age, FSTL1 mRNA expression level was significantly higher (p<0.05) in uterine leiomyoma than normal myometrium. There was no significant differences between uterine leiomyoma and adjacent normal myometrium.

CONCLUSION:

Although the mechanisms of FSTL1 gene were uncertain, FSTL1 seemed to play an important role in the growth of uterine leiomyoma, it also might be related to the regulation of uterine leiomyoma growth inhibiting factors by modulating Follistatin related protein gene (FLRG) system.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Útero / ARN / ARN Mensajero / Células Clonales / ADN Complementario / Clonación de Organismos / Folistatina / Leiomioma / Miometrio Límite: Animales / Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2004 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Útero / ARN / ARN Mensajero / Células Clonales / ADN Complementario / Clonación de Organismos / Folistatina / Leiomioma / Miometrio Límite: Animales / Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2004 Tipo del documento: Artículo