Synthesis and antidiabetic activity evaluation of benzopyrimidine derivatives / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 569-576, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1003577
Biblioteca responsable:
WPRO
ABSTRACT
@#Thioredoxin-interacting protein (TXNIP), which mainly regulates glucose homeostasis in pancreatic β cells, is a novel target in the treatment of diabetes.In this study, 4-hydroxybenzopyrimidine was used as the raw material, four nitrogen-containing rings (imidazole, methylpiperazine, pyrazole, morpholine) were introduced, benzopyrimidine skeleton with nitrogen-containing rings derivatives targeting TXNIP was designed and synthesized, and the protective effect of compounds on palmitic acid-stimulated islet β cells was investigated.A total of 20 benzopyrimidine derivatives were designed and synthesized, and the structures were confirmed by 1H NMR and ESI-MS.Pharmacological studies showed that most of the compounds exhibited protective effects on islet β cells, with better axtivity for compounds C-1, C-2, C-4 and D-2 (cell survival rate > 70%) compared with PA model group (38.3%), Among the four compounds, D-2 had the highest activity of 87.2%, so it could become a potential new anti-diabetic chemical entity.
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WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2023
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Article