In vivo pharmacokinetics and in vitro-in vivo correlation of silymarin phospholipid complex microporous osmotic pump controlled-release tablets in beagle dogs / 药学实践杂志
Journal of Pharmaceutical Practice
;
(6): 741-746, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1003621
ABSTRACT
Objective To evaluate the release characteristics in vitro, pharmacokinetics in rabbits and in vivo-in vitro correlation of silymarin phospholipid complex microporous osmotic pump controlled release tablets(SM-PC MPOP). Methods The release characteristics of SM-PC MPOP in vitro were detected by HPLC in the artificial gastric fluid. Six beagle dogs were subjected to double cycle cross control, which were given SM-PC MPOP and Legalon(30 mg/kg). The concentration of silybin in plasma was determined by HPLC and the data were processed by software. Results The cumulative release rate of SM-PC MPOP in vitro was over 85% in 12 h. The pharmacokinetics in beagle dogs showed that SM-PC MPOP and legalon conformed to double compartment first-order absorption model and the pharmacokinetic parameters were obtained tmax(3.2±0.4)and(0.9±0.1)h, Cmax(0.298 6±0.068 9)and(0.629 9±0.076 5)μg/ml, AUC0→24(2.996 8±0.583 3)and(2.268 9±0.432 8)h·μg /ml. The relative bioavailability of SM-PC MPOP was(162.21 ± 30.82)%. Conclusion SM-PC MPOP could release slowly, which could increase the relative bioavailability significantly. The correlation between the absorption in vivo and release in vitro was fine(r = 0.839 0).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Pharmaceutical Practice
Año:
2023
Tipo del documento:
Artículo
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