Prevalence of blood donation related vasovagal reactions in China: a systematic review and Meta-analysis / 中国输血杂志

ABSTRACT

【Objective】 To systematically evaluate the incidence of donation related vasovagal reactions (DRVR) in China by Meta-analysis method and discuss the risk factors of DRVR, so as to provide scientific basis for the prevention and control of DRVR. 【Methods】 Cochrane Library, PubMed, WanFang Data CNKI and other electronic databases were retrieved to collect research literature concerning the incidence and risk factors of DRVR among whole blood donors in mainland China, with the publishing duration setting from 1998 to 2020. Two reviewers independently screened the literature, extracted the data, and evaluated the methodological quality of the included studies according to the inclusion and exclusion criteria. Then Stata was used for Meta-analysis. 【Results】 A total of 63 studies involving 6 043 945 donors were included. The prevalence of DRVR was 1.0% (95% confidence interval [CI], 0.9%~1.1%, I2=99.7%, P<0.01). The prevalence of DRVR in females (1.4%, 95% CI 1.0-1.8%, I2=99.6%, P<0.01) was higher than that in males (1.1%, 95 % CI 0.8-1.4%, I2=99.6%, P<0.01). The incidence of DRVR was 1.3% (95%CI 0.8-1.8, I2=97.9%, P<0.01), 0.8% (95%CI 0.5-1.0, I2=95.0%, P<0.01), 0.4% (95%CI 0.3-0.5, I2=88.5%, P<0.01) and 0.3% (95%CI 0.1-0.6, I2=96.1%, P<0.01) in the age groups of 18-25, 26-35, 36-45 and 46-55, respectively, and the incidence of DRVR decreased with age(P<0.01). From 1998 to 2020, the incidence of DRVR decreased year by year (P<0.01). The prevalence in first-time donors (1.5%, 95% CI 1.3-1.8, I2=98.6%, P<0.01) was higher than that of regular donors (0.6%, 95% CI 0.5-0.7%, I2=97.2%, P<0.01). Anxiety was the major risk factor for DRVR. 【Conclusion】 Our results indicate that blood centers should strengthen the monitoring of DRVR. More attention should be paid to young women, more comfort given to first-time blood donors, and a more perfect system developed to reduce the occurrence of DRVR.