Hemorheological characteristics and tissue oxygen supply in people with different hemoglobin levels at high altitude / 中国输血杂志

ABSTRACT

【Objective】 To explore the difference of Hemorheological characteristics and the oxygen content of tissue on different levels of hemoglobin(Hb) which were from Tibetan plateau. 【Methods】 Volunteers with different Hb levels living in Tibetan plateau and normal Hb levels living in plain were selected and divided into 4 groups according to their source areas and different Hb levels. Group A was set as the control group, while B、C and D were set as the experimental group. In group A, 25 cases, who were required to live in plateau with Hb [male: (120~185)g·L-1, female: (115~165)g·L-1]. Group B: 17 cases, required habitat plateau with Hb [male: (185~210)g·L-1, female: (165~190)g·L-1]. In group C, 13 cases, who were required to live in plateau with Hb (male: >210 g·L-1, female: >190 g·L-1). Group D: 25 cases, who were required to live in plain with Hb [male: (120~185)g·L-1, female: (115~165)g·L-1]. 10mL of Venous blood was collected from each case, these blood samples were be tested for blood routine, hemorheology, tissue oxygen supply index, coagulation function and ATP content in erythrocyte, P50, 2, 3-DPG. 【Results】 Compared with group A, erythrocyte deformability index(TK) of group C decreased (P<0.05), while there was no significant difference between group B and D (P>0.05). Compared with group A, the blood shear rate 1 s-1, 5 s-1, and 200 s-1 of tissue oxygen supply index of group C decreased (P<0.05), the blood shear rate 50 s-1, 100 s-1 and 200 s-1of tissue oxygen supply index of group D increased (P<0.05), while there was no statistically significant difference in the blood shear rate 1 s-1, 5 s-1, 50 s-1, 100 s-1 and 200 s-1of tissue oxygen supply index of group B (P>0.05). There was no statistically significant difference in ATP, P50 and 2, 3-DPG of red blood cells among all groups(P>0.05). 【Conclusion】 In the plateau population, The tissue oxygen supply in patient with polycythemia was significantly lower than the people with normal Hb level. The tissue oxygen supply in the plain normal population was significantly higher than that in the plateau normal population.