Chronic stress as an emerging risk factor for the development and progression of glioma / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 394-407, 2024.
Article
en En
| WPRIM
| ID: wpr-1007758
Biblioteca responsable:
WPRO
ABSTRACT
Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear. This review suggests a new proposal to redivide the stress system into two parts. Neuronal activity is dominant upstream. Stress-signaling molecules produced by the neuroendocrine system are dominant downstream. We discuss the underlying molecular mechanisms by which CS impacts glioma. Potential pharmacological treatments are also summarized from the therapeutic perspective of CS.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Ansiedad
/
Neoplasias Encefálicas
/
Transducción de Señal
/
Factores de Riesgo
/
Glioma
Límite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2024
Tipo del documento:
Article