Research progress on the role and mechanism of endothelial dysfunction in hyperhomocysteine-induced atherosclerosis / 生理学报
Acta Physiologica Sinica
;
(6): 703-713, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1007785
ABSTRACT
Hyperhomocysteinemia (HHcy) is considered to be an independent risk factor for cardiovascular diseases, but the molecular mechanisms underlying its pathogenesis are not fully understood. Endothelial dysfunction is a key initiating factor in the pathogenesis of atherosclerosis, which is commonly observed in almost all HHcy-induced vascular diseases. HHcy promotes oxidative stress, inhibits nitric oxide production, suppresses hydrogen sulfide signaling pathway, promotes endothelial mesenchymal transition, activates coagulation pathways, and promotes protein N-homocysteination and cellular hypomethylation, all of which can cause endothelial dysfunction. This article reviews the specific links between HHcy and endothelial dysfunction, and highlights recent evidence that endothelial mesenchymal transition contributes to HHcy-induced vascular damage, with a hope to provide new ideas for the clinical treatment of HHcy-related vascular diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Endotelio Vascular
/
Enfermedades Cardiovasculares
/
Factores de Riesgo
/
Estrés Oxidativo
/
Hiperhomocisteinemia
/
Aterosclerosis
/
Homocisteína
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Artículo
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