Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention / 生理学报
Acta Physiologica Sinica
;
(6): 788-798, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1007791
ABSTRACT
Chronic inflammatory reaction has been established as an important sign of the occurrence and development of diabetes mellitus (DM), accompanied by the production of a large number of inflammatory factors, thus aggravating the disease progression. As an important non-invasive intervention measure to inhibit inflammation, exercise plays a very important role in the amelioration of DM. NOD-like receptor protein 3 (NLRP3) inflammasome, a regulatory factor of inflammatory response, can induce a variety of inflammatory cascades and cell death, which are closely related to glucose uptake and dyslipidemia regulation. The development of DM can be postponed with exercise. Previous studies have reported the effects of NLRP3 inflammasome on DM, but the crucial role of exercise in this process remains unclear. Therefore, this paper reviews the research progress on the improving effects of exercise intervention on the symptoms of DM by mediating NLRP3 inflammasome, providing a novel theoretical foundation for understanding the prevention and treatment of DM through exercise.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Diabetes Mellitus
/
Terapia por Ejercicio
/
Inflamasomas
/
Proteínas NLR
/
Proteína con Dominio Pirina 3 de la Familia NLR
/
Inflamación
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Artículo
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