Advances in live-imaging aging reporter mice / 生理学报
Acta Physiologica Sinica
;
(6): 836-846, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1007794
ABSTRACT
Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16Ink4a, p21Waf1/Cip1, p53 and Glb1), and discusses their applications in aging research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Envejecimiento
/
Biomarcadores
/
Proteína p53 Supresora de Tumor
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
/
Inhibidor p21 de las Quinasas Dependientes de la Ciclina
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Artículo
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