Advances in targeted delivery of proteolysis targeting chimeras in cancer therapy / 生物工程学报
Chinese Journal of Biotechnology
; (12): 3628-3643, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1007982
Biblioteca responsable:
WPRO
ABSTRACT
Small-molecule anticancer drugs inhibited tumor growth based on targeted inhibition of specific proteins, while most of oncogenic proteins are "undruggable". Proteolysis targeting chimeras (PROTAC) is an attractive and general strategy for treating cancer based on targeted degradation of oncogenic proteins. This review briefly describes the peptide-based PTOTAC and small molecule-based PROTAC. Subsequently, we summarize the development of targeted delivery of PROTAC, such as targeting molecule-mediated targeted delivery of PROTAC, nanomaterial-mediated targeted delivery of PROTAC and controllable activation of small-molecular PROTAC prodrug. Such strategies show potential application in improving tumor selectivity, overcoming off-target effect and reducing biotoxicity. At the end, the druggability of PROTAC is prospected.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Nanoestructuras
/
Proteolisis
/
Quimera Dirigida a la Proteólisis
/
Neoplasias
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2023
Tipo del documento:
Article