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Advances in the Regulation of Follicular Development by Extracellular Vesicles and Non-Coding RNAs / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 821-826, 2023.
Artículo en Chino | WPRIM | ID: wpr-1008136
ABSTRACT
Extracellular vesicles (EV),nanoscale vesicles encapsulated by phospholipid bilayers,are rich in biological molecules such as nucleic acids,metabolites,proteins,and lipids derived from parental cells.They are mainly involved in intercellular communication,signal transmission,and material transport and affect the functions of target cells.Ovulation disorders account for a higher proportion in the factors causing infertility which demonstrates increasing incidence year by year.Non-coding RNAs participate in a series of physiological and pathological processes of follicular development,playing a key role in female infertility.This review systematically introduces the types and biological roles of EV and elaborates on the regulation of follicular development from the effects of EV and non-coding RNAs on granulosa cell function,oocyte maturation,ovulation,luteal formation,and steroid hormone synthesis,providing a new idea and a breakthrough point for the diagnosis and treatment of infertility.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oogénesis / Comunicación Celular / ARN no Traducido / Vesículas Extracelulares / Células de la Granulosa / Infertilidad Límite: Femenino / Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oogénesis / Comunicación Celular / ARN no Traducido / Vesículas Extracelulares / Células de la Granulosa / Infertilidad Límite: Femenino / Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2023 Tipo del documento: Artículo