Advances in Allogeneic Chimeric Antigen Receptor T Cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 967-972, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1008154
ABSTRACT
Autologous chimeric antigen receptor(CAR)T-cell therapy has improved the prognosis of hematological malignancies.Nevertheless,allogeneic CAR-T cells have potential advantages over the autologous approach available on the market.However,allogeneic CAR-T cells may cause life-threatening graft-versus-host disease(GVHD)or be rapidly eliminated by the host immune system.In this review,we analyze the different sources of T cells for optimal allogeneic CAR-T cell therapy,describe the different approaches,and introduce the gene editing measures to produce allogeneic CAR-T cells with limited potential for GVHD and improved anti-tumor effect.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linfocitos T
/
Inmunoterapia Adoptiva
/
Trasplante de Células Madre Hematopoyéticas
/
Receptores Quiméricos de Antígenos
/
Enfermedad Injerto contra Huésped
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2023
Tipo del documento:
Artículo
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