Untargeted metabonomics study of ginseng in treatment of spleen-Qi deficiency / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 398-404, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-1008350
ABSTRACT
Ginseng has been used to treat Qi-deficiency syndrome up to now, while the therapeutic mechanism is still unclear. In order to explore the mechanism of ginseng in the treatment of Qi-deficiency constitution, the untargeted metabonomics with blood was studied based on rapid resolution high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(RRLC-Q-TOF-MS). In the results, 13 potential biomarkers were found and identified, which mainly involved in the body's antioxidant and immune functions and energy, glycerol, fatty acid, sugar metabolism and bile acid metabolism. The results of blood biochemical analysis also indicated that ginseng could regulate the body's energy metabolism, immune functions and antioxidant capacity in spleen-Qi deficiency constitution. This study revealed the mechanism of ginseng in the treatment of spleen-Qi deficiency using the blood metabonomics, which could provide technological support and scientific basis for further research on ginseng treatment of Qi-deficiency.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bazo
/
Medicamentos Herbarios Chinos
/
Biomarcadores
/
Cromatografía Líquida de Alta Presión
/
Qi
/
Metabolismo Energético
/
Metabolómica
/
Panax
/
Sistema Inmunológico
/
Medicina Tradicional China
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2020
Tipo del documento:
Artículo
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