Mechanism of stress-induced microglial activation in depression and traditional Chinese medicine regulation / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4285-4294, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1008683
Biblioteca responsable:
WPRO
ABSTRACT
Depression exists with high prevalence and heavy disease burden. Stress events play a key role in the occurrence of depression, but the pathological mechanism has not been fully clarified by reason of the complexity and heterogeneity. In recent years, neuroinflammation as a pathological mechanism of depression has received extensive attention. The activated microglia is regarded as the marker of neuroinflammation, which is an important link of stress-induced depression. Stress might induce microglia activation through pattern recognition receptors(PRR), intestinal flora, hypothalamic-pituitary-adrenal(HPA) axis, and other pathways. Cross-talk between impaired microglia function and neurobiological factors such as inflammatory cytokines, serotonin metabolism, and neuroplasticity may lead to depression. At present, a large number of studies have proved that traditional Chinese medicine(TCM) plays an anti-depressive role by inhibiting microglia activation, which may be potential treatment strategies for depressive disorder. This paper reviewed the research progress of stress-induced microglia activation in depression and summarized the mechanism of TCM against depression with regard to microglia, hoping to provide experimental evidence and consideration for TCM against depression through microglia.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Citocinas
/
Microglía
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Depresión
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Enfermedades Neuroinflamatorias
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Medicina Tradicional China
Límite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2023
Tipo del documento:
Article