Differentiation of stem cells regulated by biophysical cues / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 609-616, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1008879
ABSTRACT
Stem cells have been regarded with promising application potential in tissue engineering and regenerative medicine due to their self-renewal and multidirectional differentiation abilities. However, their fate is relied on their local microenvironment, or niche. Recent studied have demonstrated that biophysical factors, defined as physical microenvironment in which stem cells located play a vital role in regulating stem cell committed differentiation. In vitro, synthetic physical microenvironments can be used to precisely control a variety of biophysical properties. On this basis, the effect of biophysical properties such as matrix stiffness, matrix topography and mechanical force on the committed differentiation of stem cells was further investigated. This paper summarizes the approach of mechanical models of artificial physical microenvironment and reviews the effects of different biophysical characteristics on stem cell differentiation, in order to provide reference for future research and development in related fields.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Diferenciación Celular
/
Señales (Psicología)
/
Ingeniería de Tejidos
/
Medicina Regenerativa
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2023
Tipo del documento:
Artículo
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