Research progress on medical devices of polyhydroxyalkanoate in orthopedics / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
;
(12): 909-917, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1009002
ABSTRACT
OBJECTIVE@#To review the research progress of natural biomaterial polyhydroxyalkanoate (PHA) in orthopedics.@*METHODS@#The literature concerning PHA devices for bone defects, bone repair, and bone neoplasms, respectively, in recent years was extensively consulted. The three aspects of the advantages of PHA in bone repair, the preparation of PHA medical devices for bone repair and their application in orthopedics were discussed.@*RESULTS@#Due to excellent biodegradability, biocompatibility, and potential osteoinduction, PHA is a kind of good bone repair material. In addition to the traditional PHA medical implants, the use of electrostatic spinning and three-dimensional printing can be designed to various functional PHA medical devices, in order to meet the orthopedic clinical demands, including the bone regeneration, minimally invasive bone tissue repair by injection, antibacterial bone repair, auxiliary establishment of three-dimensional bone tumor model, directed osteogenic differentiation of stem cells, etc.@*CONCLUSION@#At present, PHA is a hotspot of biomaterials for translational medicine in orthopedics. Although they have not completely applied in the clinic, the advantages of repair in bone defects have been gradually reflected in tissue engineering, showing an application prospect in orthopedics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ortopedia
/
Osteogénesis
/
Artrodesis
/
Materiales Biocompatibles
/
Polihidroxialcanoatos
/
Antibacterianos
Idioma:
Chino
Revista:
Chinese Journal of Reparative and Reconstructive Surgery
Año:
2023
Tipo del documento:
Artículo
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