CD226, TIGIT and CD96 regulate NK cell function and participate in anti-tumor immunity / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
;
(12): 852-856, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1009440
ABSTRACT
CD226 is an activated receptor on the surface of natural killer (NK) cells. It competes with TIGIT and CD96 to bind to ligands such as CD155 on the surface of tumor cells and mediates the killing function of NK cells. Although TIGIT and CD96 have other binding ligands in the tumor microenvironment, they compete to bind CD115 ligands with higher affinity and inhibit the activity of NK cells, which allows tumor cells to evade killing. Therefore, studying the expression patterns of these three NK cell surface receptors in different tumors and monitoring their binding ability with ligands will help us to explore new tumor treatment strategies. This article reviews the role and mechanism of CD226, TIGIT, CD96 and other NK cell receptor molecules in regulating NK cell function in anti-tumor immune response.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Asesinas Naturales
/
Receptores Inmunológicos
/
Antígenos CD
/
Receptores de Células Asesinas Naturales
/
Ligandos
Idioma:
Chino
Revista:
Chinese Journal of Cellular and Molecular Immunology
Año:
2023
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS