Research progress on mTOR signaling pathway and regulatory T cell nutrition metabolic regulation mechanism / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
;
(12): 69-73, 2024.
Artículo
en Chino
| WPRIM
| ID: wpr-1009477
ABSTRACT
In the tumor microenvironment, metabolic reprogramming can impact metabolic characteristics of T cells, thus inducing immunosuppression to promote tumor immune escape. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in regulating diverse functions of various immune cells. This review mainly focuses on the molecular mechanism of mTOR signaling in regulating cellular energy metabolism process, and the activation status of mTOR signaling under different nutritional environments. In addition, it also summarizes the role of the mTOR signaling in regulatory T cell (Tregs) metabolism and function in current studies, and evaluates the potential of mTOR as a clinical immunotherapeutic target and its current application challenges.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Terapia de Inmunosupresión
/
Linfocitos T Reguladores
/
Sirolimus
/
Serina-Treonina Quinasas TOR
/
Reprogramación Metabólica
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cellular and Molecular Immunology
Año:
2024
Tipo del documento:
Artículo
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