Research progress on immunotherapy based on NK cells for hepatocellular carcinoma / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
;
(12): 80-88, 2024.
Artículo
en Chino
| WPRIM
| ID: wpr-1009479
ABSTRACT
Hepatocellular carcinoma (HCC) is well characterized as a heterogeneous disease. Its late-stage diagnosis and chemotherapy resistance make it one of the refractory tumors in China. Natural killer (NK) cells play a significant role in immune surveillance. However, NK cells become dysfunctional in the progression of HCC, leading to tumor immune escape. This article reviews the recent progress on different strategies of NK cell-based immunotherapy in treating HCC, including direct adoptive NK cell transfer, gene engineering in NK cell, NK cell receptor targeting, immunosuppressive microenvironment modification, and tumor toxicity enhancement by cytokines or traditional Chinese medicine. These NK cell-based strategies have shown promising therapeutic potential.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Asesinas Naturales
/
Carcinoma Hepatocelular
/
Receptores de Células Asesinas Naturales
/
Microambiente Tumoral
/
Inmunoterapia
/
Neoplasias Hepáticas
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cellular and Molecular Immunology
Año:
2024
Tipo del documento:
Artículo
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