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Combination of stromal vascular fraction and Ad-COMP-Ang1 gene therapy improves long-term therapeutic efficacy for diabetes-induced erectile dysfunction / 亚洲男科学杂志(英文版)
Asian j. androl ; Asian j. androl;(6): 465-472, 2018.
Article en En | WPRIM | ID: wpr-1009603
Biblioteca responsable: WPRO
ABSTRACT
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects. In the present study, we aimed to test if the combination of SVF and Ad-COMP-Ang1 could extend the erection effect in diabetic ED. We found that the combination therapy showed a long-term effect in restoring erectile function through enhanced penile endothelial and neural cell regeneration. Combination therapy with SVF and Ad-COMP-Ang1 notably restored cavernous endothelial cell numbers, pericyte numbers, endothelial cell-cell junctions, decreased cavernous endothelial cell permeability, and promoted neural regeneration for at least 4 weeks in diabetic mice. In summary, this is an initial description of the long-term effect of combination therapy with SVF and Ad-COMP-Ang1 in restoring erectile function through a dual effect on endothelial and neural cell regeneration. Such combination therapy may have therapeutic potential for the treatment of diabetic ED.
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Texto completo: 1 Índice: WPRIM Asunto principal: Permeabilidad / Erección Peniana / Endotelio Vascular / Terapia Genética / Angiopoyetina 1 / Trasplante de Células Madre Mesenquimatosas / Diabetes Mellitus Experimental / Disfunción Eréctil / Uniones Intercelulares Límite: Animals Idioma: En Revista: Asian j. androl Año: 2018 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Permeabilidad / Erección Peniana / Endotelio Vascular / Terapia Genética / Angiopoyetina 1 / Trasplante de Células Madre Mesenquimatosas / Diabetes Mellitus Experimental / Disfunción Eréctil / Uniones Intercelulares Límite: Animals Idioma: En Revista: Asian j. androl Año: 2018 Tipo del documento: Article