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Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 73-80, 2024.
Artículo en Chino | WPRIM | ID: wpr-1010112
ABSTRACT
V-Raf murine sarcoma viral oncogene homolog B (BRAF) alteration is one of the most essential driver genes of non-small cell lung cancer (NSCLC). BRAF encodes serine/threonine protein kinases, and its mutations typically lead to protein compositional activation, thereby activating the mitogen-activated protein kinase kinase (MEK) signaling pathway. A promising new approach for the treatment of mutated BRAF and/or downstream MEK may provide customized treatment opportunities for BRAF driven NSCLC patients. However, combination therapy is necessary to overcome the difficulties such as short duration of benefit, poor therapeutic effect of non-V600 BRAF mutations and susceptibility to drug resistance. This article reviewed the progress in structural characteristics, related signaling pathways, mutation types of BRAF gene, and the clinical pathological relationship between BRAF mutations and NSCLC, as well as the therapy, in order to provide more evidences for clinical doctors to make treatment decisions.
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Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Quinasas de Proteína Quinasa Activadas por Mitógenos / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Neoplasias Pulmonares / Mutación Límite: Animales / Humanos Idioma: Chino Revista: Chinese Journal of Lung Cancer Año: 2024 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Quinasas de Proteína Quinasa Activadas por Mitógenos / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Neoplasias Pulmonares / Mutación Límite: Animales / Humanos Idioma: Chino Revista: Chinese Journal of Lung Cancer Año: 2024 Tipo del documento: Artículo