Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2 / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 277-288, 2024.
Artículo
en Inglés
| WPRIM
| ID: wpr-1010331
ABSTRACT
As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, and its elevated levels have been shown to contribute to AS. Lp-PLA2 is closely related to a variety of lipoproteins, and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine (oxPC) to produce lysophosphatidylcholine (lysoPC). Moreover, macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability. This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biomarcadores
/
1-Alquil-2-acetilglicerofosfocolina Esterasa
/
Aterosclerosis
/
Placa Aterosclerótica
/
Lipoproteínas
/
Medicina Tradicional China
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese journal of integrative medicine
Año:
2024
Tipo del documento:
Artículo
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