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Atoh1 regulation in the cochlea: more than just transcription / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 146-155, 2019.
Artículo en Inglés | WPRIM | ID: wpr-1010393
ABSTRACT
More than 80% of all cases of deafness are related to the death or degeneration of cochlear hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these cells leads to permanent hearing loss. Therefore, the regeneration of lost hair cells is an important goal for the treatment of deafness. Atoh1 is a basic helix-loop-helix (bHLH) transcription factor that is critical in both the development and regeneration of cochlear hair cells. Atoh1 is transcriptionally regulated by several signaling pathways, including Notch and Wnt signalings. At the post-translational level, it is regulated through the ubiquitin-proteasome pathway. In vitro and in vivo studies have revealed that manipulation of these signaling pathways not only controls development, but also leads to the regeneration of cochlear hair cells after damage. Recent progress toward understanding the signaling networks involved in hair cell development and regeneration has led to the development of new strategies to replace lost hair cells. This review focuses on our current understanding of the signaling pathways that regulate Atoh1 in the cochlea.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factores de Transcripción / Transducción de Señal / Diferenciación Celular / Cóclea / Ubiquitina / Complejo de la Endopetidasa Proteasomal / Beta Catenina / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Vía de Señalización Wnt / Células Ciliadas Auditivas Límite: Humanos Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factores de Transcripción / Transducción de Señal / Diferenciación Celular / Cóclea / Ubiquitina / Complejo de la Endopetidasa Proteasomal / Beta Catenina / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Vía de Señalización Wnt / Células Ciliadas Auditivas Límite: Humanos Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2019 Tipo del documento: Artículo