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Experiments that led to the first gene-edited babies: the ethical failings and the urgent need for better governance / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 32-38, 2019.
Artículo en Inglés | WPRIM | ID: wpr-1010441
ABSTRACT
The rapid developments of science and technology in China over recent decades, particularly in biomedical research, have brought forward serious challenges regarding ethical governance. Recently, Jian-kui HE, a Chinese scientist, claimed to have "created" the first gene-edited babies, designed to be naturally immune to the human immunodeficiency virus (HIV). The news immediately triggered widespread criticism, denouncement, and debate over the scientific and ethical legitimacy of HE's genetic experiments. China's guidelines and regulations have banned germline genome editing on human embryos for clinical use because of scientific and ethical concerns, in accordance with the international consensus. HE's human experimentation has not only violated these Chinese regulations, but also breached other ethical and regulatory norms. These include questionable scientific value, unreasonable risk-benefit ratio, illegitimate ethics review, invalid informed consent, and regulatory misconduct. This series of ethical failings of HE and his team reveal the institutional failure of the current ethics governance system which largely depends on scientist's self-regulation. The incident highlights the need for urgent improvement of ethics governance at all levels, the enforcement of technical and ethical guidelines, and the establishment of laws relating to such bioethical issues.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Infecciones por VIH / China / Receptores CCR5 / Mala Conducta Profesional / Formularios de Consentimiento / Ética Médica / Técnicas de Inactivación de Genes / Sistemas CRISPR-Cas / Edición Génica / Experimentación Humana Límite: Femenino / Humanos / Recién Nacido / Embarazo País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Infecciones por VIH / China / Receptores CCR5 / Mala Conducta Profesional / Formularios de Consentimiento / Ética Médica / Técnicas de Inactivación de Genes / Sistemas CRISPR-Cas / Edición Génica / Experimentación Humana Límite: Femenino / Humanos / Recién Nacido / Embarazo País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2019 Tipo del documento: Artículo