Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 687-692, 2019.
Article
en En
| WPRIM
| ID: wpr-1010475
Biblioteca responsable:
WPRO
ABSTRACT
The objective of this study was to assess the angiogenic potential expressed as a quotient of vascular endothelial growth factor A (VEGF-A), as an indicator of proangiogenic activity, and the circulating receptors (soluble VEGF receptor protein R1 (sVEGFR-1) and sVEGFR-2), as indicators of the effect of angiogenic inhibition, depending on the concentrations of matrix metalloproteinase 2 (MMP-2) and MMP-9 and their tissue inhibitor 1 (TIMP-1) and TIMP-2 in the plasma of patients with lower extremity artery disease (LEAD). These blood parameters in patients with intermittent claudication (IC) and critical limb ischemia (CLI) were compared for select clinical and biochemical features. Stimulation of angiogenesis in the plasma of individuals with LEAD was evident as indicated by the significant increase in VEGF-A concentration along with reduced inhibition depending on circulating receptors sVEGFR-1 and sVEGFR-2. Critical ischemia was associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 concentrations than in the case of IC.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Regulación de la Expresión Génica
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Inhibidor Tisular de Metaloproteinasa-1
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Inhibidor Tisular de Metaloproteinasa-2
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Metaloproteinasa 9 de la Matriz
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Inhibidores de la Angiogénesis
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Extremidad Inferior
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Receptor 1 de Factores de Crecimiento Endotelial Vascular
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Receptor 2 de Factores de Crecimiento Endotelial Vascular
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Factor A de Crecimiento Endotelial Vascular
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Claudicación Intermitente
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Zhejiang University. Science. B
Año:
2019
Tipo del documento:
Article