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Cellulose nanofibril matrix drives the dynamic formation of spheroids / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 922-934, 2023.
Artículo en Inglés | WPRIM | ID: wpr-1010572
ABSTRACT
Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 h) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Inglés Revista: Journal of Zhejiang University. Science. B Año: 2023 Tipo del documento: Artículo