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Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 1289-1308, 2023.
Artículo en Inglés | WPRIM | ID: wpr-1010604
ABSTRACT
The physiological functions of endogenous amyloid-β (Aβ), which plays important role in the pathology of Alzheimer's disease (AD), have not been paid enough attention. Here, we review the multiple physiological effects of Aβ, particularly in regulating synaptic transmission, and the possible mechanisms, in order to decipher the real characters of Aβ under both physiological and pathological conditions. Some worthy studies have shown that the deprivation of endogenous Aβ gives rise to synaptic dysfunction and cognitive deficiency, while the moderate elevation of this peptide enhances long term potentiation and leads to neuronal hyperexcitability. In this review, we provide a new view for understanding the role of Aβ in AD pathophysiology from the perspective of physiological meaning.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Péptidos beta-Amiloides / Potenciación a Largo Plazo / Transmisión Sináptica / Enfermedad de Alzheimer / Hipocampo Límite: Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Péptidos beta-Amiloides / Potenciación a Largo Plazo / Transmisión Sináptica / Enfermedad de Alzheimer / Hipocampo Límite: Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2023 Tipo del documento: Artículo