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Crosstalk Between Peripheral Innervation and Pancreatic Ductal Adenocarcinoma / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 1717-1731, 2023.
Artículo en Inglés | WPRIM | ID: wpr-1010643
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy resistance, leading to a poor overall prognosis. Emerging evidence shows that the peripheral nerve is an important non-tumor component in the tumor microenvironment that regulates tumor growth and immune escape. The crosstalk between the neuronal system and PDAC has become a hot research topic that may provide novel mechanisms underlying tumor progression and further uncover promising therapeutic targets. In this review, we highlight the mechanisms of perineural invasion and the role of various types of tumor innervation in the progression of PDAC, summarize the potential signaling pathways modulating the neuronal-cancer interaction, and discuss the current and future therapeutic possibilities for this condition.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Nervios Periféricos / Transducción de Señal / Carcinoma Ductal Pancreático / Microambiente Tumoral Límite: Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2023 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Nervios Periféricos / Transducción de Señal / Carcinoma Ductal Pancreático / Microambiente Tumoral Límite: Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2023 Tipo del documento: Artículo