Magnesium promotes vascularization and osseointegration in diabetic states / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 10-10, 2024.
Artículo
en Inglés
| WPRIM
| ID: wpr-1010723
ABSTRACT
Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants successfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg2+ promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data suggested that Mg2+ promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oseointegración
/
Células Endoteliales
/
Diabetes Mellitus Experimental
/
Factor 2 Relacionado con NF-E2
/
Proteína 1 Asociada A ECH Tipo Kelch
/
Magnesio
Límite:
Animales
Idioma:
Inglés
Revista:
International Journal of Oral Science
Año:
2024
Tipo del documento:
Artículo
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