c-Jun N-terminal kinase signaling pathway in acetaminophen-induced liver injury / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 1223-1228, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1010930
ABSTRACT
Acetaminophen (APAP) is the most common antipyretic, analgesic and anti-inflammatory drug, but its overdose often leads to acute liver injury, even acute liver failure, and death in some severe cases. At present, there is still a lack of specific treatments. The c-Jun N-terminal kinase (JNK) signal pathway is one of the potential therapeutic targets identified in recent years in overdose APAP-induced acute liver injury. This article reviews the JNK signaling pathway of APAP in liver metabolism, the activation of JNK signaling pathway and the amplification of oxidative stress, other pathways or cellular processes related to JNK signaling pathway, and the possible challenges of drugs targeting JNK, so as to provide direction and feasibility analysis for further research and clinical application of JNK signaling pathway targets in APAP hepatotoxicity, and to provide reference for searching for other targets.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Proteínas Quinasas JNK Activadas por Mitógenos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas
/
Hígado
/
Acetaminofén
/
Ratones Endogámicos C57BL
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Critical Care Medicine
Año:
2023
Tipo del documento:
Artículo
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