Drug discovery by targeting the protein-protein interactions involved in autophagy
Acta Pharmaceutica Sinica B
; (6): 4373-4390, 2023.
Article
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| WPRIM
| ID: wpr-1011188
Biblioteca responsable:
WPRO
ABSTRACT
Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for degradation. Protein-protein interactions (PPIs) play a crucial role at many stages of autophagy, which present formidable but attainable targets for autophagy regulation. Moreover, selective regulation of PPIs tends to have a lower risk in causing undesired off-target effects in the context of a complicated biological network. Thus, small-molecule regulators, including peptides and peptidomimetics, targeting the critical PPIs involved in autophagy provide a new opportunity for innovative drug discovery. This article provides general background knowledge of the critical PPIs involved in autophagy and reviews a range of successful attempts on discovering regulators targeting those PPIs. Successful strategies and existing limitations in this field are also discussed.
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WPRIM
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En
Revista:
Acta Pharmaceutica Sinica B
Año:
2023
Tipo del documento:
Article