Correlation between the percentage of epicardial adipose tissue in the pericardium and early cardiac function changes in type 2 diabetic patients without heart failure / 西安交通大学学报(医学版)

ABSTRACT

【Objective】 To explore the correlation between the percentage of epicardial adipose tissue（EAT） and cardiac function in type 2 diabetes mellitus without heart failure. 【Methods】 We recruited diabetic inpatients and random non-diabetic inpatients who underwent CTA examinations in the Imaging Department of The First Affiliated Hospital， Xi’an Jiaotong University， from 2012 to 2014 as the research subjects. Their clinical data， laboratory examinations， echocardiography， and EAT quantification based on cardiac CTA were analyzed retrospectively. The parameters were compared between the two groups. Then the correlation between cardiac function parameters and EAT parameters was analyzed. 【Results】 Compared with those in control group， type 2 diabetic patients without heart failure had lower left ventricular stroke volume （61.41±15.95 vs. 79.41±15.19， P=0.047）， and the percentage of EAT in the pericardium， plasma total cholesterol， and low-density lipoprotein cholesterol were all related to it. The correlation coefficients were -0.501， -0.136， and -0.377. The percentage of EAT in the pericardium still had a moderately linear negative correlation with SV when the other factors were under control （r=-0.470， P<0.001）. 【Conclusion】 The percentage of EAT is asseated with early decreased left ventricular SV in patients with type 2 diabetes. It can be used as a sensitive index to quantify cardiac function abnormalities in type 2 diabetes.