Detection of promoter and 3' UTR mutation in A20 gene of a case with T cell lymphoma cell leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 851-854, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-1011872
ABSTRACT
Objective:
To clarify the characteristics of the A20 regulatory changes by analyzing mutations in the non-coding region of the A20 gene in patients with T-cell lymphoma leukemia (T-LCL) .Methods:
PCR and nucleotide sequence analysis were used to detect mutations in the non-coding region of the A20 gene, and DNA samples from PBMCs of 52 cases of T-LCL and 99 healthy controls.Results:
A missense mutation (c.-672T>G) was detected in the A20 gene promoter from one T-LCL patient, which has been registered as a SNP (rs139054966) in gene bank. Meanwhile, a new mutation was detected in the 3' UTR mRNA (3916 (C>G) ) . These two mutations were absent in other T-LCL samples and controls.Conclusion:
The rs139054966 (c.-672T>G) and 3916 (C>G) mutations in the A20 gene were detected in T-LCL patients for the first time. There was also rs139054966 located on the binding region of the transcription factor P53, and its significance remained to be further clarified.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Leucemia
/
Linfoma de Células T
/
Regiones Promotoras Genéticas
/
Regiones no Traducidas 3'
/
Mutación
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2018
Tipo del documento:
Artículo
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