EGFR inhibitor AG1478 enhances oxaliplatin induced apoptosis in HCT116 cells / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 1121-1126, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-1013789
ABSTRACT
Aim To investigate the effect of tyrosine kinase inhibitor AG1478 combined with oxaliplatin (OXA) on apoptosis of colorectal cancer HCT116 cells. Methods MTT assay was used to measure the effect of AG1478 combined with OXA on proliferation of HCT116 cells. RT-qPCR was used to detect the mRNA expression levels of p53, caspase-3, Bcl-2 and Bax. Western blot was used to detect the proteins expression of p53, caspase-3, cleaved-caspase 3, Bcl-2, Bax, p62, LC3 and IL-6. Results Both OXA and AG1478 inhibited the proliferation of HCT116 (P < 0. 01). IC
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
2023
Tipo del documento:
Artículo
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