Role of p300 in susceptibility of atrial Hbrillation in aged mice / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 180-186, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-1014313
ABSTRACT
Aim To explore the role of cotranscriptional activator p300 in regulating the electrical remodeling of atrial myocytes in aging mouse, which resulted in atrial fibrillation. Methods The left atrial appendage tissues of 5 , 13 and 18monthold C57BL/6 mice were collected respectively. Western blot was used to detect the protein expression levels of p300, L type calcium channel (Cavl. 2) and aging related protein p53/p21. Acute enzymatic hydrolysis was used to isolate single atrial myocytes, and the wholecell patchclamp technique was used to detect the Ltype calcium current (I
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Pharmacological Bulletin
Año:
2021
Tipo del documento:
Artículo
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