Effect of glucosinolates on improvement of cognitive impairment in APP/PS1 double transgenic mice by regulating AKT/NFkB pathway / 中国药理学通报

ABSTRACT

Aim To investigate the effects of acteoside (AS) on BRAIN AKT and NFkB in APP/PS1 double transgenic mice. Methods Fifty healthy APP/PS1 transgenic mice, half male and half female, and 10 control C57 mice were given the drug by gavage for 60 consecutive days. During the period of administration, and new object recognition experiments were conducted to detect the expression of AKT and NFkB related proteins in the hippocampus and cortex of the mice. Results Compared with model group, AS could significantly improve the nesting behavior of mice and en- hance the interest of exploring new objects in mice with Alzheimer' s disease. At the same time, compared with model group, AS significantly reduced the ratio of NFkB p-p65 /NFkB p65 in hippocampus and cortical tissues, and increased the ratio of p-AKT-308 /AKT and p-AKT473 /AKT. Conclusions AS may inhibit the apoptosis of nerve cells and protect nerve cells through the regulation of AKT and NFkB to treat neurodegenerative diseases.