Study on protective effect of pedunculoside on acute myocardial ischemia/reperfusion injury in rats / 中国药理学通报

ABSTRACT

Aim To explore the protective effect of pedunculoside (PE) on myocardial ischemia/reperfusion injury. Methods Rat model of acute myocardial ischemia reperfusion injury was prepared by ligating the left anterior descending coronary artery (LAD) of the heart for 30 min and reperfusion for 24 h, and the rats were randomly divided into seven groups (re = 10) sham group (Sham), acute myocardial ischemia reperfusion injury model group (M), captopril group (Capt), metoprolol group (MT), PE low, medium and high dosage groups (2. 5, 5 and 10 mg · kg