Bioequivalence of metformin hydrochloride sustained-release tablets in healthy subjects / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 408-413, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-1015049
ABSTRACT
AIM:
To study the bioequivalence of two metformin hydrochloride sustained-release tablets in Chinese healthy subjects.METHODS:
A randomized, open-label, two-period, crossover study design was adopted in the study. In fasting test 36 and in fed test 23 healthy subjects were given a single oral dose of metformin hydrochloride sustained-release tablet (0.5 g). The concentration of metformin in plasma was measured by HPLC-MS/MS. The pharmacokinetic parameters were calculated by WinNonlin 7.0 program, and statistical analysis were performed by using SAS9.4 statistics software.RESULTS:
In the fasting test, the pharmacokinetic parameters of metformin of the test (T) and reference(R) preparation were as follow C
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Año:
2021
Tipo del documento:
Artículo
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